In the 64bit version of 4.50 keyboard shortcuts (like CTRL+P, CTRL+S, SHIFT+S...) doesn't work while the TWAIN-dailog is open.
There is no problem with this in the 32bit version of 4.50.
I'm running Windows 10 Pro - 1703 build 15063.674.
There is no problem with this in the 32bit version of 4.50.
I'm running Windows 10 Pro - 1703 build 15063.674.